Moody:
Call me braindead but can you please elaborate since this joke you probably only get if you are native English speaker.
It's what we call a PUN, Moody.
"How do you make a HORMONE?"
sounds like
"How do you make a WHORE (= prostitute) MOAN (i.e complain)?"
The fun is supposed to be when the person being asked the question launches into a detailed explanation of the manufacture of synthetic estrogens which bind and influence oestrogen receptors, enabling the alteration and control of aspects of our reproductive health... at which point the speaker gives them a "you idiot" look and says, more slowly, "No, no... how you make a WHORE MOAN?"